Q-omics provides the consensus-scored SND1-IT1 profile across patient tissues and cancer cell-line models. SND1-IT1 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, SND1-IT1 is differentially expressed in 10, with the highest sampling consensus in HNSC. Additionally, SND1-IT1 RNA expression shows 11,873 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight ACC, HNSC, and THYM as cancer lineages where SND1-IT1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SND1-IT1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SND1-IT1 survival associations across molecular data types. SND1-IT1 RNA expression shows survival associations in the most cancer types (24). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SND1-IT1 RNA expression–survival associations across cancer types. High SND1-IT1 expression shows unfavorable associations in ACC, BLCA, LIHC and KIRC, but favorable associations in CESC and LGG. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify ACC as the clearest survival context for SND1-IT1 RNA expression.
This table summarizes SND1-IT1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for SND1-IT1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SND1-IT1 shows lower tumor expression in KICH and higher tumor expression in HNSC, STAD, COAD, BLCA and BRCA. The HNSC box plot shows higher SND1-IT1 RNA expression in tumor versus normal tissue (log2 FC = +0.080, t-test p < 0.001).
This table shows molecular features associated with SND1-IT1 in patient tissues and cancer cell lines. In patient samples, SND1-IT1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, SND1-IT1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_SCLC, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and NCI60_ALL.
