SND1-IT1

Across TCGA pan-cancer cohorts, SND1-IT1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SND1-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SND1-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SND1-IT1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, STAD, and KICH are the cancer types where SND1-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SND1-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+0.080	<.001	9	view →
STAD	All	All	+0.513	.002	5	view →
KICH	All	All	−0.045	.001	5	view →
COAD	All	II,III,IV	+0.034	.009	5	view →
BLCA	Female	III,IV	+0.131	.043	3	view →
BRCA	Female	All	+0.179	.032	2	view →
LIHC	Female	II,III,IV	+0.025	.008	2	view →
ESCA	All	All	+0.398	.035	1	view →
KIRC	Female	All	+0.041	.025	1	view →
THCA	Male	All	−0.038	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SND1-IT1–HNSC

Open the HNSC breakdown →