SMUG1

Across TCGA cell cohorts, SMUG1 mutation is significantly associated with the mutation status of many other genes, with 397 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMUG1-associated genes across cancer lineages are GPLD1, AMPD2, and PCID2. Each is linked with SMUG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMUG1-to-partner and partner-to-SMUG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPLD1 grouped by SMUG1-low versus SMUG1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMUG1→partner) and Y-score (partner→SMUG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GPLD1 →	+4.502	+5.066	.007	.007	1	3
BLOOD_Leukemia	AMPD2 →	+4.309	+4.560	.007	.007	1	3
BLOOD_Leukemia	PCID2 →	+5.894	+5.321	.002	.002	1	3
BLOOD_Leukemia	HAO1 →	+4.894	+4.894	.004	.004	1	2
BLOOD_Leukemia	CIAO3 →	+4.309	+4.560	.007	.007	1	2
BLOOD_Leukemia	GGA2 →	+4.309	+4.560	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 397 associations by consensus.

GPLD1 by SMUG1 expression — LUNG_SCLC

Explore this box plot interactively →