SMUG1

Across TCGA pan-cancer cohorts, SMUG1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of SMUG1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SMUG1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SMUG1 is over-expressed in tumor.

HNSC, KIRC, and LUAD are the cancer types where SMUG1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMUG1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.857	<.001	12	view →
KIRC	All	IV	+0.427	<.001	12	view →
LUAD	Male	All	+0.852	<.001	11	view →
BLCA	Female	III,IV	+1.274	<.001	10	view →
LIHC	Female	II,III,IV	+0.947	<.001	9	view →
KIRP	All	II,III,IV	+0.558	<.001	9	view →
LUSC	Female	II,III,IV	+1.148	<.001	8	view →
STAD	All	II,III,IV	+0.589	<.001	8	view →
COAD	All	II,III,IV	+0.278	<.001	7	view →
BRCA	All	III,IV	+0.608	<.001	6	view →
CHOL	All	All	+1.228	<.001	5	view →
UCEC	All	All	+0.361	.004	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

SMUG1–HNSC

Open the HNSC breakdown →