SMIM8

Across TCGA patient cohorts, SMIM8 mutation is significantly associated with the RNA expression of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMIM8-associated genes across cancer lineages are RN7SL248P, MIR6515, and IL9. Each is linked with SMIM8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMIM8-to-partner and partner-to-SMIM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by SMIM8-low versus SMIM8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM8→partner) and Y-score (partner→SMIM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.139	+4.722	<.001	.004	3	1
UCEC	MIR6515 →	+0.436	+4.335	<.001	.007	3	1
SKCM	IL9 →	+0.427	+5.037	<.001	.009	3	1
SKCM	MIR3684 →	+0.782	+5.771	<.001	.003	3	1
SKCM	MIR4323 →	+0.600	+4.979	<.001	.009	3	1
UCEC	RNU4-35P →	+0.402	+3.453	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

RN7SL248P by SMIM8 expression — UCEC

Explore this box plot interactively →