SMIM8

Across TCGA pan-cancer cohorts, SMIM8 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated SMIM8 data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher SMIM8 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SMIM8 expression acts as an unfavorable survival marker, although some lineages such as PAAD and LUSC show a favorable association.

PAAD, BLCA, and LIHC are the cancer types where SMIM8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	OS	Median	All	0.535	0.268	<.001	55	view →
BLCA	DFS	Quartile	IV	0.092	0.416	.001	43	view →
LIHC	DFS	Tertile	All	0.435	0.633	<.001	41	view →
LUSC	OS	Median	All	0.824	0.724	<.001	30	view →
ACC	DFS	Median	All	0.466	0.697	.007	24	view →
THYM	DFS	Median	All	0.942	0.791	.004	23	view →
KIRC	OS	Quartile	All	0.858	0.740	.003	22	view →
KICH	DFS	Quartile	III,IV	0.390	1.000	.006	22	view →
ESCA	OS	Quartile	All	0.507	0.759	.002	21	view →
KIRP	OS	Median	III,IV	0.177	0.717	.005	19	view →
SCLC	OS	Quartile	All	0.460	1.000	.012	14	view →
READ	OS	Quartile	II,III,IV	0.870	0.314	.009	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

SMIM8–PAAD (OS)

Open the PAAD breakdown →