SMARCA5

Across TCGA patient cohorts, SMARCA5 mutation is significantly associated with the RNA expression of many other genes, with 3,786 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMARCA5-associated genes across cancer lineages are RNA5SP412, FANCG, and DUX4L47. Each is linked with SMARCA5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMARCA5-to-partner and partner-to-SMARCA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by SMARCA5-low versus SMARCA5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMARCA5→partner) and Y-score (partner→SMARCA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.367	+1.565	<.001	<.001	3	3
UCEC	FANCG →	+0.454	+1.423	<.001	<.001	3	3
CESC	DUX4L47 →	+0.111	+4.539	<.001	.008	3	2
CESC	OR8S21P →	+0.118	+4.669	.004	.007	3	2
HNSC	MTND1P27 →	+0.055	+5.241	<.001	.007	3	2
UCEC	CCL5 →	+1.017	+1.423	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,786 associations by consensus.

RNA5SP412 by SMARCA5 expression — UCEC

Explore this box plot interactively →