SMARCA5

Across TCGA pan-cancer cohorts, SMARCA5 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SMARCA5 data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SMARCA5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SMARCA5 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

UVM, KIRC, and LIHC are the cancer types where SMARCA5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	All	0.254	0.776	<.001	85	view →
KIRC	OS	Tertile	All	0.734	0.549	<.001	81	view →
LIHC	DFS	Median	III,IV	0.187	0.465	<.001	41	view →
UCS	DFS	Median	IV	0.952	0.367	.001	36	view →
MESO	OS	Quartile	III,IV	0.243	0.472	.015	29	view →
LUSC	DFS	Tertile	III,IV	0.310	0.935	.002	22	view →
SKCM	DFS	Quartile	All	0.792	0.639	.009	17	view →
GBM	DFS	Median	All	0.415	0.166	<.001	15	view →
READ	OS	Tertile	IV	1.000	0.565	.017	13	view →
LGG	OS	Quartile	All	0.754	0.937	.005	13	view →
SCLC	DFS	Median	II,III,IV	0.687	0.411	.016	12	view →
BRCA	DFS	Median	III,IV	0.570	0.381	.011	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SMARCA5–UVM (DFS)

Open the UVM breakdown →