SMAD7

Across TCGA patient cohorts, SMAD7 protein abundance is significantly associated with the RNA expression of many other genes, with 555 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SMAD7-associated genes across cancer lineages are MCF2, MICU1, and UHRF1BP1L. Each is linked with SMAD7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMAD7-to-partner and partner-to-SMAD7 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMAD7 versus MCF2 in GBM, with a Pearson correlation of 0.83.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD7→partner) and Y-score (partner→SMAD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MCF2 →	+1.028	+1.012	.004	.002	3	1
GBM	MICU1 →	+0.812	+1.012	<.001	.002	3	1
GBM	UHRF1BP1L →	+0.394	+1.012	.001	.002	3	1
GBM	GRM6 →	-0.903	-1.333	.002	.002	3	1
GBM	RASGRF2 →	+1.410	+1.012	.002	.002	3	1
GBM	SMYD1 →	+0.208	+1.012	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 555 associations by consensus.

SMAD7 vs MCF2 — GBM

Explore this scatter interactively →