SMAD7

Across TCGA pan-cancer cohorts, SMAD7 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SMAD7’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SMAD7 RNA is repressed in tumor relative to normal tissue. In most cancer types SMAD7 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, HNSC, and LUAD are the cancer types where SMAD7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMAD7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−1.255	<.001	11	view →
HNSC	All	III,IV	+0.996	<.001	11	view →
LUAD	Female	II,III,IV	−1.129	<.001	8	view →
LUSC	Female	II,III,IV	−1.969	<.001	7	view →
KICH	All	All	−0.991	<.001	7	view →
THCA	All	All	−0.440	<.001	7	view →
BLCA	Male	All	−1.146	<.001	6	view →
STAD	Male	II,III,IV	+0.915	.004	6	view →
KIRP	Male	All	−0.802	<.001	4	view →
CHOL	All	All	+1.736	<.001	3	view →
UCEC	All	IV	−2.025	.044	2	view →
PRAD	All	All	−0.467	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SMAD7–COAD

Open the COAD breakdown →