SMAD7

Across TCGA pan-cancer cohorts, SMAD7 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SMAD7 data layer compared with 8 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher SMAD7 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SMAD7 expression acts as an unfavorable survival marker, although some lineages such as LGG and KIRC show a favorable association.

LUSC, LGG, and ACC are the cancer types where SMAD7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Quartile	II,III,IV	0.253	0.538	<.001	84	view →
LGG	OS	Median	All	0.863	0.752	<.001	42	view →
ACC	DFS	Median	II,III,IV	0.382	0.675	.005	38	view →
KIRC	DFS	Quartile	III,IV	0.768	0.474	.007	35	view →
LUAD	OS	Median	II,III,IV	0.579	0.330	.001	33	view →
SKCM	DFS	Quartile	All	0.251	0.141	.002	33	view →
MESO	OS	Quartile	All	0.486	0.726	.019	26	view →
OV	DFS	Quartile	II,III,IV	0.434	0.328	.018	18	view →
COAD	OS	Quartile	II,III,IV	0.909	0.675	.010	13	view →
BRCA	OS	Median	III,IV	0.879	0.777	.015	13	view →
TGCT	DFS	Tertile	All	0.739	0.942	.023	12	view →
CESC	DFS	Quartile	All	0.412	0.710	.004	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SMAD7–LUSC (OS)

Open the LUSC breakdown →