SLC66A3

Across TCGA patient cohorts, SLC66A3 mutation is significantly associated with the RNA expression of many other genes, with 137 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC66A3-associated genes across cancer lineages are RPS29P33, H3P46, and RPL23AP90. Each is linked with SLC66A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC66A3-to-partner and partner-to-SLC66A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS29P33 grouped by SLC66A3-low versus SLC66A3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC66A3→partner) and Y-score (partner→SLC66A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPS29P33 →	+0.169	+7.930	<.001	.008	3	2
UCEC	H3P46 →	+0.130	+4.069	<.001	.008	3	2
UCEC	RPL23AP90 →	+0.530	+3.004	<.001	.006	3	1
UCEC	RN7SKP290 →	+0.360	+3.358	<.001	.006	3	1
UCEC	RPS29P32 →	+0.855	+3.277	<.001	.002	3	1
UCEC	CICP28 →	+0.037	+3.029	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 137 associations by consensus.

RPS29P33 by SLC66A3 expression — LUAD

Explore this box plot interactively →