SLC66A3

Across TCGA pan-cancer cohorts, SLC66A3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SLC66A3 data layer compared with 3 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher SLC66A3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SLC66A3 expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

SKCM, KIRC, and UVM are the cancer types where SLC66A3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.391	0.276	<.001	92	view →
KIRC	DFS	Median	All	0.932	0.792	<.001	87	view →
UVM	OS	Tertile	All	0.372	0.726	<.001	78	view →
BLCA	DFS	Median	All	0.371	0.613	.002	65	view →
KIRP	DFS	Quartile	II,III,IV	0.172	1.000	.003	62	view →
LGG	OS	Median	All	0.350	0.541	<.001	54	view →
MESO	OS	Tertile	All	0.699	0.441	.001	40	view →
GBM	DFS	Median	All	0.185	0.333	<.001	33	view →
LIHC	DFS	Quartile	All	0.196	0.365	.009	26	view →
CESC	DFS	Tertile	All	0.614	0.842	<.001	24	view →
LUAD	DFS	Median	IV	0.807	0.270	.003	21	view →
THYM	DFS	Median	III,IV	1.000	0.365	.001	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SLC66A3–SKCM (OS)

Open the SKCM breakdown →