SLC5A6

Across TCGA cell cohorts, SLC5A6 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLC5A6-associated genes across cancer lineages are MDFIC2, UBE2QL1, and POU3F4. Each is linked with SLC5A6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC5A6-to-partner and partner-to-SLC5A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MDFIC2 grouped by SLC5A6-low versus SLC5A6-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC5A6→partner) and Y-score (partner→SLC5A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MDFIC2 →	+0.155	+4.977	<.001	.007	3	1
LARGE_INTESTINE	UBE2QL1 →	+0.285	+3.766	<.001	.004	3	1
BLOOD_Lymphoma	POU3F4 →	+1.280	+5.169	<.001	.001	3	1
BLOOD_Lymphoma	OR2F1 →	+0.146	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	MYH13 →	+0.037	+4.191	<.001	.007	3	1
BLOOD_Lymphoma	SI →	+0.017	+4.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

MDFIC2 by SLC5A6 expression — SKIN

Explore this box plot interactively →