SLC5A6

Across TCGA pan-cancer cohorts, SLC5A6 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated SLC5A6 data layer compared with 6 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SLC5A6 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SLC5A6 expression acts as an unfavorable survival marker, although some lineages such as STAD and READ show a favorable association.

KIRC, ACC, and MESO are the cancer types where SLC5A6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.520	0.725	<.001	142	view →
ACC	OS	Median	All	0.454	0.781	<.001	119	view →
MESO	OS	Median	All	0.406	0.659	<.001	116	view →
KIRP	DFS	Median	All	0.365	0.727	<.001	98	view →
UVM	DFS	Tertile	All	0.351	0.792	.001	70	view →
LGG	DFS	Median	All	0.631	0.842	<.001	54	view →
STAD	DFS	Median	All	0.710	0.541	.001	53	view →
LIHC	DFS	Median	All	0.350	0.514	<.001	42	view →
LUAD	DFS	Median	All	0.739	0.879	<.001	37	view →
CESC	OS	Tertile	All	0.714	0.873	.007	34	view →
SARC	OS	Quartile	All	0.413	0.645	<.001	32	view →
UCEC	OS	Quartile	All	0.875	0.963	.004	30	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

SLC5A6–KIRC (OS)

Open the KIRC breakdown →