SLC5A6

Across TCGA pan-cancer cohorts, SLC5A6 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of SLC5A6’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SLC5A6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC5A6 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, BLCA, and LUAD are the cancer types where SLC5A6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC5A6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+2.111	<.001	12	view →
BLCA	Male	III,IV	+2.091	<.001	12	view →
LUAD	Female	III,IV	+1.310	<.001	11	view →
STAD	Female	All	+2.129	<.001	10	view →
LUSC	Male	II,III,IV	+2.009	<.001	8	view →
HNSC	All	III,IV	+0.730	<.001	8	view →
THCA	All	All	−0.302	<.001	8	view →
UCEC	All	III,IV	+1.832	<.001	6	view →
LIHC	Male	All	+1.116	<.001	6	view →
KIRP	All	II,III,IV	+0.592	.003	6	view →
READ	All	All	+2.130	<.001	5	view →
KICH	All	All	−0.584	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

SLC5A6–COAD

Open the COAD breakdown →