SLC1A4

Across TCGA cell cohorts, SLC1A4 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC1A4-associated genes across cancer lineages are TCF21, MSGN1, and GP9. Each is linked with SLC1A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC1A4-to-partner and partner-to-SLC1A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCF21 grouped by SLC1A4-low versus SLC1A4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC1A4→partner) and Y-score (partner→SLC1A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TCF21 →	+0.011	+4.705	<.001	.003	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	GP9 →	+0.081	+4.518	.001	<.001	3	1
LARGE_INTESTINE	OR10W1 →	+0.016	+3.977	<.001	.001	3	1
LARGE_INTESTINE	TAFA1 →	+0.274	+3.688	<.001	.002	3	1
LARGE_INTESTINE	C14orf180 →	+0.183	+4.477	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

TCF21 by SLC1A4 expression — BLOOD_Leukemia

Explore this box plot interactively →