SLC1A4

Across TCGA pan-cancer cohorts, SLC1A4 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SLC1A4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SLC1A4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC1A4 is over-expressed in tumor.

KIRC, HNSC, and LUAD are the cancer types where SLC1A4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC1A4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.963	<.001	12	view →
HNSC	Male	III,IV	+1.650	<.001	11	view →
LUAD	Male	II,III,IV	+1.299	<.001	11	view →
COAD	Female	All	+1.151	<.001	11	view →
KIRP	All	II,III,IV	+1.001	<.001	9	view →
LIHC	Female	II,III,IV	+1.661	<.001	8	view →
THCA	Female	III,IV	+0.706	<.001	7	view →
LUSC	Female	All	+2.414	<.001	6	view →
BRCA	All	II,III,IV	+0.904	<.001	6	view →
STAD	All	II,III,IV	+0.793	<.001	6	view →
CHOL	All	All	+1.176	.004	2	view →
BLCA	Female	All	+1.011	.031	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SLC1A4–KIRC

Open the KIRC breakdown →