SLC1A4

Across TCGA pan-cancer cohorts, SLC1A4 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SLC1A4 data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SLC1A4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SLC1A4 expression acts as an unfavorable survival marker, although some lineages such as BRCA and LUAD show a favorable association.

ACC, UVM, and LIHC are the cancer types where SLC1A4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.395	0.838	<.001	95	view →
UVM	DFS	Median	All	0.419	0.752	<.001	82	view →
LIHC	OS	Median	All	0.707	0.841	<.001	77	view →
KICH	DFS	Median	III,IV	0.223	0.943	<.001	66	view →
BRCA	DFS	Tertile	III,IV	0.936	0.793	<.001	55	view →
LUAD	OS	Median	III,IV	0.770	0.548	<.001	52	view →
SCLC	OS	Median	All	0.708	0.434	<.001	50	view →
LGG	DFS	Median	All	0.830	0.638	<.001	50	view →
KIRC	OS	Tertile	All	0.741	0.541	<.001	41	view →
UCEC	DFS	Median	III,IV	0.702	0.433	.003	30	view →
PAAD	DFS	Tertile	All	0.473	0.179	<.001	29	view →
STAD	DFS	Quartile	All	0.751	0.542	.003	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SLC1A4–ACC (OS)

Open the ACC breakdown →