SLAMF6

Across TCGA cell cohorts, SLAMF6 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SLAMF6-associated genes across cancer lineages are OR1M1, CLRN1, and TBATA. Each is linked with SLAMF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLAMF6-to-partner and partner-to-SLAMF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1M1 grouped by SLAMF6-low versus SLAMF6-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLAMF6→partner) and Y-score (partner→SLAMF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR1M1 →	+0.016	+5.643	<.001	.002	3	1
LUNG_NSCLC_LUAD	CLRN1 →	+0.020	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	TBATA →	+0.178	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	SCN10A →	+0.003	+4.078	<.001	.009	3	1
SKIN	OXT →	+0.063	+4.977	<.001	.007	3	1
SKIN	AVPR1B →	+0.006	+5.415	.007	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OR1M1 by SLAMF6 expression — LUNG_SCLC

Explore this box plot interactively →