SKA1

Across TCGA patient cohorts, SKA1 protein abundance is significantly associated with the protein abundance of many other proteins, with 16,482 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SKA1-associated proteins across cancer lineages are SMC2, SMC4, and TOP2A. Each is linked with SKA1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SKA1-to-partner and partner-to-SKA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SKA1 versus SMC2 in OV, with a Pearson correlation of 0.70.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SKA1→partner) and Y-score (partner→SKA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SMC2 →	+1.298	+1.375	<.001	<.001	3	6
OV	SMC4 →	+1.220	+1.690	<.001	<.001	3	6
UCEC	TOP2A →	+1.043	+0.547	.001	.006	3	6
OV	KIF11_T926 →	+1.890	+1.036	<.001	<.001	3	6
LUAD	KNTC1 →	+1.184	+1.367	<.001	<.001	3	6
LUAD	NCAPD2 →	+1.070	+1.047	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,482 associations by consensus.

SKA1 vs SMC2 — OV

Explore this scatter interactively →