SKA1

Across TCGA pan-cancer cohorts, SKA1 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of SKA1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SKA1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SKA1 is over-expressed in tumor.

HNSC, BLCA, and KIRP are the cancer types where SKA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SKA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.890	<.001	12	view →
BLCA	Male	IV	+3.190	<.001	11	view →
KIRP	Male	III,IV	+1.289	<.001	11	view →
KIRC	Male	IV	+1.188	<.001	11	view →
LUSC	Male	III,IV	+3.554	<.001	9	view →
LUAD	Male	III,IV	+2.766	<.001	9	view →
LIHC	Male	II,III,IV	+1.997	<.001	9	view →
COAD	Female	II,III,IV	+1.161	<.001	9	view →
STAD	Female	All	+2.197	<.001	8	view →
THCA	All	III,IV	+0.438	.001	8	view →
UCEC	All	III,IV	+3.391	<.001	6	view →
BRCA	All	II,III,IV	+2.113	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

SKA1–HNSC

Open the HNSC breakdown →