SIX4

Across TCGA patient cohorts, SIX4 protein abundance is significantly associated with the RNA expression of many other genes, with 11,437 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SIX4-associated genes across cancer lineages are SIX1, PRKDC, and KIF15. Each is linked with SIX4 in more than 4 cancer types. Because this analysis shows association rather than direction, both SIX4-to-partner and partner-to-SIX4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIX4 versus SIX1 in LSCC, with a Pearson correlation of 0.75.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX4→partner) and Y-score (partner→SIX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SIX1 →	+1.223	+0.614	<.001	<.001	3	5
LSCC	PRKDC →	+0.515	+0.399	.003	.006	3	4
UCEC	KIF15 →	+0.928	+0.290	<.001	.009	3	4
UCEC	CDCA3 →	+0.819	+0.353	<.001	.002	3	3
HNSC	TULP1 →	+0.434	+0.409	<.001	.001	3	3
HNSC	CEP250 →	+0.516	+0.434	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,437 associations by consensus.

SIX4 vs SIX1 — LSCC

Explore this scatter interactively →