SIX4

Across TCGA pan-cancer cohorts, SIX4 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated SIX4 data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SIX4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SIX4 expression acts as an unfavorable survival marker, although some lineages such as LAML and LUSC show a favorable association.

UVM, KIRP, and KIRC are the cancer types where SIX4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.445	0.794	<.001	148	view →
KIRP	DFS	Median	II,III,IV	0.291	0.873	.001	102	view →
KIRC	DFS	Median	All	0.558	0.683	<.001	98	view →
THCA	OS	Median	II,III,IV	0.790	0.963	.001	61	view →
LAML	DFS	Median	All	0.586	0.332	<.001	46	view →
SARC	OS	Median	All	0.627	0.853	<.001	44	view →
COAD	DFS	Tertile	All	0.599	0.750	.001	34	view →
LUSC	OS	Tertile	All	0.730	0.570	.001	29	view →
LIHC	DFS	Quartile	II,III,IV	0.128	0.353	.002	25	view →
BRCA	DFS	Tertile	III,IV	0.944	0.831	.018	22	view →
STAD	OS	Median	All	0.399	0.647	.004	19	view →
PAAD	OS	Median	All	0.325	0.633	.002	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

SIX4–UVM (OS)

Open the UVM breakdown →