SHARPIN

Across TCGA cell cohorts, SHARPIN mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SHARPIN-associated genes across cancer lineages are TTLL8, C10orf53, and OR5H8. Each is linked with SHARPIN in more than 1 cancer types. Because this analysis shows association rather than direction, both SHARPIN-to-partner and partner-to-SHARPIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTLL8 grouped by SHARPIN-low versus SHARPIN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHARPIN→partner) and Y-score (partner→SHARPIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TTLL8 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	C10orf53 →	+0.015	+4.217	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR5H8 →	+0.017	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

TTLL8 by SHARPIN expression — LARGE_INTESTINE

Explore this box plot interactively →