SHARPIN

Across TCGA pan-cancer cohorts, SHARPIN RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated SHARPIN data layer compared with 2 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SHARPIN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SHARPIN expression acts as an unfavorable survival marker, although some lineages such as SCLC and LGG show a favorable association.

KIRC, LIHC, and UVM are the cancer types where SHARPIN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.727	0.859	<.001	110	view →
LIHC	OS	Quartile	All	0.618	0.823	<.001	92	view →
UVM	OS	Tertile	All	0.385	0.804	.002	87	view →
CESC	DFS	Tertile	All	0.488	0.690	.009	38	view →
UCS	OS	Quartile	II,III,IV	0.391	0.885	.008	34	view →
HNSC	OS	Median	All	0.701	0.797	.003	26	view →
COAD	DFS	Quartile	II,III,IV	0.679	0.817	.009	23	view →
LUAD	DFS	Median	IV	0.254	0.745	.010	23	view →
KIRP	DFS	Tertile	All	0.790	0.932	.003	22	view →
KICH	DFS	Quartile	III,IV	0.056	0.819	.010	21	view →
PAAD	OS	Median	All	0.538	0.684	.010	18	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

SHARPIN–KIRC (DFS)

Open the KIRC breakdown →