SHARPIN

Across TCGA pan-cancer cohorts, SHARPIN RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SHARPIN’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SHARPIN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SHARPIN is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where SHARPIN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SHARPIN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.875	<.001	12	view →
KIRC	Male	IV	+0.814	<.001	12	view →
COAD	All	IV	+1.035	<.001	11	view →
KIRP	Male	II,III,IV	+0.608	<.001	11	view →
LIHC	Male	II,III,IV	+1.596	<.001	9	view →
LUAD	All	III,IV	+0.854	<.001	8	view →
BLCA	All	All	+0.508	<.001	8	view →
LUSC	All	II,III,IV	+0.478	<.001	7	view →
STAD	Male	III,IV	+1.061	<.001	6	view →
BRCA	All	III,IV	+0.849	<.001	6	view →
CHOL	Female	All	+2.083	<.001	5	view →
READ	All	All	+0.474	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SHARPIN–HNSC

Open the HNSC breakdown →