SH3BP1

Across TCGA cell cohorts, SH3BP1 mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SH3BP1-associated genes across cancer lineages are CABP2, KCNG4, and HMGB4. Each is linked with SH3BP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3BP1-to-partner and partner-to-SH3BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CABP2 grouped by SH3BP1-low versus SH3BP1-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BP1→partner) and Y-score (partner→SH3BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CABP2 →	+0.026	+5.614	<.001	.002	3	1
PANCREAS	KCNG4 →	+0.013	+5.614	<.001	.002	3	1
PANCREAS	HMGB4 →	+0.022	+5.000	<.001	.006	3	1
PANCREAS	MBD3L3 →	+0.110	+5.614	<.001	.002	3	1
PANCREAS	TFDP3 →	+0.013	+5.000	<.001	.006	3	1
PANCREAS	CCER1 →	+0.006	+5.614	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

CABP2 by SH3BP1 expression — PANCREAS

Explore this box plot interactively →