SH3BP1

Across TCGA pan-cancer cohorts, SH3BP1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SH3BP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SH3BP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SH3BP1 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

KIRC, COAD, and THCA are the cancer types where SH3BP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SH3BP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.414	<.001	12	view →
COAD	Female	III,IV	−1.215	<.001	12	view →
THCA	Male	II,III,IV	+1.052	<.001	11	view →
HNSC	Male	All	+1.216	<.001	10	view →
KIRP	All	All	+0.820	<.001	9	view →
STAD	All	All	+1.180	<.001	7	view →
LUSC	Female	II,III,IV	+1.838	<.001	6	view →
BLCA	Male	All	+1.731	.015	6	view →
BRCA	All	All	+0.551	<.001	6	view →
LIHC	Female	All	+0.868	<.001	4	view →
UCEC	All	All	+0.636	.011	4	view →
CHOL	Male	All	+2.338	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SH3BP1–KIRC

Open the KIRC breakdown →