SH3BP1

Across TCGA pan-cancer cohorts, SH3BP1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated SH3BP1 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher SH3BP1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SH3BP1 expression acts as an unfavorable survival marker, although some lineages such as STAD and SCLC show a favorable association.

STAD, KIRC, and HNSC are the cancer types where SH3BP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Tertile	All	0.755	0.557	<.001	80	view →
KIRC	OS	Quartile	All	0.560	0.763	.001	67	view →
HNSC	OS	Median	All	0.615	0.794	<.001	45	view →
LAML	DFS	Quartile	All	0.224	0.642	<.001	36	view →
SCLC	OS	Tertile	All	0.812	0.521	.005	30	view →
PAAD	DFS	Tertile	II,III,IV	0.539	0.298	.007	27	view →
ACC	OS	Quartile	IV	0.221	0.906	.006	23	view →
BLCA	DFS	Median	All	0.554	0.461	.011	17	view →
LIHC	OS	Quartile	III,IV	0.153	0.613	.005	17	view →
CESC	OS	Median	All	0.907	0.834	.017	14	view →
UCEC	OS	Tertile	All	0.880	0.955	.009	14	view →
BRCA	OS	Tertile	All	0.794	0.581	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

SH3BP1–STAD (DFS)

Open the STAD breakdown →