SH2B3

Across TCGA patient cohorts, SH2B3 mutation is significantly associated with the RNA expression of many other genes, with 550 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH2B3-associated genes across cancer lineages are CHCHD2P3, PABPC1L2B-AS1, and TCP11X2. Each is linked with SH2B3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2B3-to-partner and partner-to-SH2B3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHCHD2P3 grouped by SH2B3-low versus SH2B3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2B3→partner) and Y-score (partner→SH2B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHCHD2P3 →	+0.136	+2.018	<.001	.003	3	2
BLCA	PABPC1L2B-AS1 →	+0.056	+8.051	<.001	<.001	3	2
HNSC	TCP11X2 →	+0.041	+5.505	<.001	.004	3	2
HNSC	LINC02063 →	+0.662	+5.015	<.001	.009	3	2
LUSC	RNA5SP175 →	+0.722	+3.938	<.001	.004	3	2
LUSC	MIR4296 →	+0.538	+3.578	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 550 associations by consensus.

CHCHD2P3 by SH2B3 expression — UCEC

Explore this box plot interactively →