SH2B3

Across TCGA pan-cancer cohorts, SH2B3 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated SH2B3 data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SH2B3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SH2B3 expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

UVM, KIRC, and KIRP are the cancer types where SH2B3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.264	0.740	<.001	71	view →
KIRC	OS	Quartile	All	0.734	0.545	.001	50	view →
KIRP	DFS	Quartile	III,IV	0.417	0.792	.003	44	view →
MESO	OS	Quartile	All	0.236	0.481	.004	41	view →
LAML	DFS	Quartile	All	0.216	0.529	<.001	40	view →
HNSC	DFS	Quartile	III,IV	0.692	0.446	.001	39	view →
LGG	OS	Tertile	All	0.323	0.515	<.001	37	view →
CHOL	DFS	Quartile	All	0.819	0.119	.001	22	view →
PAAD	OS	Median	II,III,IV	0.670	0.435	.001	16	view →
LUSC	OS	Tertile	All	0.359	0.482	.025	14	view →
LUAD	OS	Quartile	II,III,IV	0.847	0.657	.012	13	view →
LIHC	DFS	Median	II,III,IV	0.321	0.503	.007	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

SH2B3–UVM (DFS)

Open the UVM breakdown →