SH2B3

Across TCGA pan-cancer cohorts, SH2B3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SH2B3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SH2B3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SH2B3 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

HNSC, KIRC, and STAD are the cancer types where SH2B3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SH2B3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.687	<.001	11	view →
KIRC	Female	All	+1.641	<.001	11	view →
STAD	Male	II,III,IV	+1.537	<.001	8	view →
LUSC	Female	All	−1.257	<.001	8	view →
LUAD	Female	II,III,IV	−0.829	<.001	8	view →
UCEC	All	All	−1.336	<.001	6	view →
COAD	All	All	−0.383	.002	6	view →
LIHC	All	All	+0.476	.002	4	view →
BRCA	All	All	−0.205	.011	4	view →
ESCA	All	All	+1.681	<.001	3	view →
PAAD	All	All	−1.127	.009	2	view →
KICH	Female	All	−0.736	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SH2B3–HNSC

Open the HNSC breakdown →