SFTPC

Across TCGA patient cohorts, SFTPC mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFTPC-associated genes across cancer lineages are RN7SL248P, SNORD127, and RNA5SP419. Each is linked with SFTPC in more than 1 cancer types. Because this analysis shows association rather than direction, both SFTPC-to-partner and partner-to-SFTPC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by SFTPC-low versus SFTPC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFTPC→partner) and Y-score (partner→SFTPC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.124	+4.400	<.001	.006	3	2
UCEC	SNORD127 →	+1.048	+4.463	<.001	<.001	3	2
UCEC	RNA5SP419 →	+1.229	+3.492	<.001	.003	3	2
BLCA	SERPINE4P →	+0.149	+7.640	<.001	.009	3	1
CESC	RNU6-1140P →	+0.391	+5.539	<.001	.004	3	1
CESC	PTP4A1P3 →	+0.123	+6.569	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

RN7SL248P by SFTPC expression — UCEC

Explore this box plot interactively →