SEPTIN7

Across TCGA patient cohorts, SEPTIN7 mutation is significantly associated with the RNA expression of many other genes, with 1,483 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEPTIN7-associated genes across cancer lineages are RN7SL248P, TRAJ11, and GABRG2. Each is linked with SEPTIN7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPTIN7-to-partner and partner-to-SEPTIN7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by SEPTIN7-low versus SEPTIN7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN7→partner) and Y-score (partner→SEPTIN7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.054	+3.059	<.001	.005	3	2
COAD	TRAJ11 →	+1.072	+4.543	<.001	.005	3	2
CESC	GABRG2 →	+0.271	+4.409	<.001	.006	3	1
CESC	NEUROD6 →	+0.018	+4.812	<.001	.006	3	1
CESC	OR4M1 →	+0.028	+5.342	<.001	.002	3	1
CESC	MAGEB10 →	+0.121	+4.653	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,483 associations by consensus.

RN7SL248P by SEPTIN7 expression — UCEC

Explore this box plot interactively →