SEPTIN7

Across TCGA pan-cancer cohorts, SEPTIN7 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SEPTIN7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SEPTIN7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SEPTIN7 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where SEPTIN7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEPTIN7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.063	<.001	11	view →
KIRC	Male	All	+0.558	<.001	11	view →
LIHC	Female	II,III,IV	+0.951	<.001	9	view →
KICH	Female	All	−1.290	<.001	7	view →
KIRP	All	IV	+1.112	.003	7	view →
THCA	All	All	−0.304	<.001	7	view →
UCEC	All	All	−1.043	<.001	6	view →
CHOL	Male	All	+1.905	<.001	5	view →
ESCA	All	All	+0.771	.007	2	view →
BLCA	All	IV	−0.675	.007	2	view →
PRAD	All	All	−0.409	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SEPTIN7–HNSC

Open the HNSC breakdown →