SEPTIN7

Across TCGA pan-cancer cohorts, SEPTIN7 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SEPTIN7 data layer compared with 5 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher SEPTIN7 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEPTIN7 expression acts as an unfavorable survival marker, although some lineages such as UCS and KIRC show a favorable association.

MESO, CESC, and ACC are the cancer types where SEPTIN7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	II,III,IV	0.264	0.483	<.001	100	view →
CESC	OS	Tertile	III,IV	0.185	0.680	.005	78	view →
ACC	DFS	Tertile	All	0.324	0.737	<.001	76	view →
UCS	OS	Tertile	III,IV	0.554	0.258	.014	60	view →
KIRC	DFS	Tertile	All	0.873	0.671	<.001	55	view →
UVM	DFS	Quartile	All	0.313	0.823	.002	52	view →
BLCA	OS	Quartile	All	0.647	0.787	.004	51	view →
KICH	DFS	Tertile	II,III,IV	0.471	0.962	.001	50	view →
KIRP	DFS	Quartile	III,IV	0.208	0.856	.015	38	view →
LIHC	OS	Median	All	0.707	0.843	<.001	37	view →
LGG	OS	Median	All	0.850	0.938	<.001	36	view →
SKCM	DFS	Quartile	All	0.275	0.130	<.001	27	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SEPTIN7–MESO (DFS)

Open the MESO breakdown →