SEPTIN7

Across TCGA cell cohorts, SEPTIN7 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SEPTIN7-associated genes across cancer lineages are OR14K1, PATE4, and HSFY1. Each is linked with SEPTIN7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPTIN7-to-partner and partner-to-SEPTIN7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR14K1 grouped by SEPTIN7-low versus SEPTIN7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN7→partner) and Y-score (partner→SEPTIN7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR14K1 →	+0.081	+4.437	<.001	.004	3	1
LARGE_INTESTINE	PATE4 →	+0.049	+4.510	<.001	.001	3	1
SKIN	HSFY1 →	+0.013	+6.022	<.001	.001	3	1
SKIN	SPATA31D4 →	+0.170	+4.977	<.001	.007	3	1
SKIN	KRTAP1-3 →	+0.033	+6.022	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR14K1 by SEPTIN7 expression — LARGE_INTESTINE

Explore this box plot interactively →