SEMA3C

Across TCGA patient cohorts, SEMA3C RNA expression is significantly associated with the protein abundance of many other proteins, with 20,527 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SEMA3C-associated proteins across cancer lineages are VIM, P3H4, and PPFIBP1. Each is linked with SEMA3C in more than 7 cancer types. Because this analysis shows association rather than direction, both SEMA3C-to-partner and partner-to-SEMA3C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEMA3C versus VIM in UCEC, with a Pearson correlation of 0.24.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA3C→partner) and Y-score (partner→SEMA3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VIM →	+0.510	+0.869	.002	.003	3	8
OV	P3H4 →	+0.688	+1.105	<.001	<.001	3	8
OV	PPFIBP1 →	+0.447	+1.040	<.001	.002	3	8
OV	CRTAP →	+0.733	+1.489	<.001	<.001	3	8
CCRCC	ITGAV →	+0.527	+1.518	<.001	<.001	3	7
OV	MMP14 →	+0.666	+1.415	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,527 associations by consensus.

SEMA3C vs VIM — UCEC

Explore this scatter interactively →