SEMA3C

Across TCGA pan-cancer cohorts, SEMA3C RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SEMA3C’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SEMA3C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SEMA3C is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.

HNSC, KIRC, and KICH are the cancer types where SEMA3C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEMA3C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+2.704	<.001	11	view →
KIRC	All	II,III,IV	−0.711	.002	7	view →
KICH	All	II,III,IV	+2.004	<.001	6	view →
BRCA	Female	All	−1.076	<.001	6	view →
COAD	All	All	−0.577	.006	6	view →
LUAD	All	II,III,IV	+0.844	.001	5	view →
CHOL	Male	All	+4.021	<.001	4	view →
READ	All	All	−1.212	.006	3	view →
UCEC	All	III,IV	−1.354	.042	2	view →
LUSC	All	All	+0.599	.015	2	view →
THCA	All	All	−0.394	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SEMA3C–HNSC

Open the HNSC breakdown →