SEMA3C

Across TCGA pan-cancer cohorts, SEMA3C RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SEMA3C data layer compared with 10 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SEMA3C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEMA3C expression acts as an unfavorable survival marker, although some lineages such as BRCA and DLBC show a favorable association.

CESC, HNSC, and KIRP are the cancer types where SEMA3C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Tertile	All	0.406	0.714	<.001	102	view →
HNSC	OS	Median	All	0.598	0.724	<.001	83	view →
KIRP	OS	Median	II,III,IV	0.594	0.880	<.001	77	view →
PAAD	OS	Tertile	All	0.216	0.504	<.001	64	view →
KIRC	DFS	Quartile	III,IV	0.283	0.611	.001	34	view →
BRCA	DFS	Quartile	III,IV	0.877	0.690	.001	30	view →
DLBC	DFS	Median	II,III,IV	1.000	0.535	.015	24	view →
THCA	OS	Tertile	III,IV	0.870	1.000	.013	12	view →
LUAD	OS	Quartile	All	0.584	0.721	.008	12	view →
UVM	OS	Quartile	All	0.967	0.657	.001	12	view →
PRAD	DFS	Tertile	All	0.900	0.710	.001	12	view →
LAML	DFS	Quartile	All	0.350	0.754	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SEMA3C–CESC (DFS)

Open the CESC breakdown →