SEMA3C

Across TCGA cell cohorts, SEMA3C mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SEMA3C-associated genes across cancer lineages are SPATA16, CFAP100, and SP8. Each is linked with SEMA3C in more than 1 cancer types. Because this analysis shows association rather than direction, both SEMA3C-to-partner and partner-to-SEMA3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA16 grouped by SEMA3C-low versus SEMA3C-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA3C→partner) and Y-score (partner→SEMA3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SPATA16 →	+0.158	+3.321	<.001	.006	3	1
BLOOD_Lymphoma	CFAP100 →	+0.212	+3.727	<.001	.005	3	1
BLOOD_Lymphoma	SP8 →	+0.343	+3.717	<.001	.005	3	1
BLOOD_Lymphoma	FAM166C →	+0.027	+3.459	<.001	.004	3	1
BLOOD_Lymphoma	PLA2G2E →	+0.026	+3.584	<.001	.004	3	1
BLOOD_Lymphoma	TRIM49D2 →	+0.435	+3.192	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

SPATA16 by SEMA3C expression — BLOOD_Lymphoma

Explore this box plot interactively →