SEC31A

Across TCGA patient cohorts, SEC31A mutation is significantly associated with the RNA expression of many other genes, with 3,104 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC31A-associated genes across cancer lineages are FBXO22, RN7SL96P, and KRTAP21-3. Each is linked with SEC31A in more than 2 cancer types. Because this analysis shows association rather than direction, both SEC31A-to-partner and partner-to-SEC31A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXO22 grouped by SEC31A-low versus SEC31A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC31A→partner) and Y-score (partner→SEC31A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FBXO22 →	+0.463	+2.076	<.001	<.001	3	3
BLCA	RN7SL96P →	+0.130	+3.231	<.001	.002	3	3
ESCA	KRTAP21-3 →	+0.535	+4.476	<.001	.005	3	3
STAD	MIR7702 →	+0.437	+3.330	<.001	.008	3	3
UCEC	MED31 →	+0.331	+2.076	<.001	<.001	3	3
UCEC	LINC02195 →	+0.397	+1.862	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,104 associations by consensus.

FBXO22 by SEC31A expression — UCEC

Explore this box plot interactively →