SEC31A

Across TCGA pan-cancer cohorts, SEC31A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SEC31A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SEC31A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SEC31A is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, HNSC, and LUAD are the cancer types where SEC31A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEC31A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+0.757	<.001	12	view →
HNSC	All	All	+0.496	<.001	9	view →
LUAD	All	II,III,IV	+0.603	<.001	8	view →
THCA	All	All	−0.327	<.001	8	view →
LIHC	All	II,III,IV	+0.717	<.001	7	view →
BRCA	Female	All	+0.488	<.001	6	view →
CHOL	Male	All	+1.466	<.001	3	view →
KIRP	Female	II,III,IV	+0.548	.022	3	view →
KICH	All	All	−0.439	.010	3	view →
COAD	Female	All	−0.529	.010	2	view →
UCEC	All	All	−0.378	.016	2	view →
PRAD	All	All	+0.194	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SEC31A–KIRC

Open the KIRC breakdown →