SEC31A

Across TCGA pan-cancer cohorts, SEC31A RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated SEC31A data layer compared with 7 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher SEC31A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEC31A expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

BLCA, KIRC, and CESC are the cancer types where SEC31A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	All	0.152	0.538	<.001	98	view →
KIRC	DFS	Tertile	All	0.730	0.541	<.001	96	view →
CESC	DFS	Median	All	0.443	0.629	<.001	68	view →
STAD	OS	Tertile	II,III,IV	0.552	0.815	.007	44	view →
LUSC	DFS	Tertile	III,IV	0.251	0.680	<.001	39	view →
MESO	DFS	Tertile	All	0.315	0.669	.012	33	view →
LGG	OS	Median	All	0.755	0.871	<.001	28	view →
HNSC	DFS	Tertile	IV	0.437	0.295	.013	26	view →
LIHC	DFS	Quartile	All	0.183	0.332	.005	23	view →
SARC	OS	Median	All	0.419	0.788	<.001	19	view →
KICH	DFS	Median	II,III,IV	0.574	0.918	.005	18	view →
ACC	DFS	Median	IV	0.495	0.066	.001	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

SEC31A–BLCA (DFS)

Open the BLCA breakdown →