SEC23B

Across TCGA patient cohorts, SEC23B mutation is significantly associated with the RNA expression of many other genes, with 2,352 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC23B-associated genes across cancer lineages are NDUFA5P5, RNU6-896P, and RNA5SP139. Each is linked with SEC23B in more than 2 cancer types. Because this analysis shows association rather than direction, both SEC23B-to-partner and partner-to-SEC23B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFA5P5 grouped by SEC23B-low versus SEC23B-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC23B→partner) and Y-score (partner→SEC23B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	NDUFA5P5 →	+0.064	+4.257	<.001	.007	3	3
SKCM	RNU6-896P →	+0.067	+4.421	<.001	.003	3	2
LIHC	RNA5SP139 →	+0.273	+5.305	<.001	.003	3	2
BLCA	HMGN2P39 →	+1.077	+4.533	<.001	.005	3	2
SKCM	CXorf49B →	+0.030	+3.186	<.001	<.001	3	2
SKCM	MTND4LP19 →	+0.056	+3.084	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,352 associations by consensus.

NDUFA5P5 by SEC23B expression — LUSC

Explore this box plot interactively →