SEC23B

Across TCGA pan-cancer cohorts, SEC23B RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated SEC23B data layer compared with 9 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SEC23B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SEC23B expression acts as an unfavorable survival marker, although some lineages such as UCEC and KIRC show a favorable association.

UCEC, KIRC, and SCLC are the cancer types where SEC23B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	III,IV	0.824	0.491	.001	64	view →
KIRC	DFS	Tertile	All	0.735	0.447	.001	41	view →
SCLC	DFS	Median	II,III,IV	0.738	0.447	.009	34	view →
LIHC	OS	Quartile	All	0.628	0.840	.001	33	view →
LAML	DFS	Median	All	0.250	0.504	<.001	32	view →
READ	DFS	Tertile	All	0.862	0.547	.007	26	view →
CESC	OS	Median	III,IV	0.502	0.782	.017	24	view →
UVM	DFS	Tertile	II,III,IV	0.399	0.694	.006	20	view →
UCS	DFS	Median	II,III,IV	0.282	0.564	.013	20	view →
COAD	DFS	Tertile	III,IV	0.532	0.802	.007	15	view →
LUSC	OS	Quartile	All	0.327	0.460	.018	11	view →
OV	OS	Tertile	All	0.807	0.870	.031	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

SEC23B–UCEC (DFS)

Open the UCEC breakdown →