SEC13

Across TCGA patient cohorts, SEC13 mutation is significantly associated with the RNA expression of many other genes, with 602 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC13-associated genes across cancer lineages are MIR6817, HSCB, and PHF5A. Each is linked with SEC13 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC13-to-partner and partner-to-SEC13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6817 grouped by SEC13-low versus SEC13-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC13→partner) and Y-score (partner→SEC13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR6817 →	+0.450	+5.080	<.001	.004	3	2
UCEC	HSCB →	+0.379	+2.695	.002	<.001	3	2
UCEC	PHF5A →	+0.421	+2.056	.003	.005	3	2
UCEC	DNAJC8 →	+0.328	+1.786	.006	.008	3	2
UCEC	GTF2A2 →	+0.452	+3.111	.003	<.001	3	2
UCEC	LINS1 →	+0.291	+2.684	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 602 associations by consensus.

MIR6817 by SEC13 expression — SKCM

Explore this box plot interactively →