SEC13

Across TCGA pan-cancer cohorts, SEC13 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SEC13’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where SEC13 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SEC13 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

BLCA, COAD, and LIHC are the cancer types where SEC13 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEC13 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	+0.910	<.001	10	view →
COAD	Female	All	+0.847	<.001	10	view →
LIHC	Female	II,III,IV	+1.133	<.001	9	view →
LUAD	All	III,IV	+0.637	<.001	9	view →
HNSC	All	All	+0.236	.002	7	view →
UCEC	All	III,IV	+0.703	<.001	6	view →
BRCA	All	III,IV	+0.577	<.001	6	view →
CHOL	All	II,III,IV	+1.080	.001	5	view →
STAD	All	II,III,IV	+0.518	.002	4	view →
KIRC	Male	All	−0.235	.002	4	view →
LUSC	All	All	+0.187	.002	4	view →
KICH	All	All	−0.394	.016	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SEC13–BLCA

Open the BLCA breakdown →