SEC13

Across TCGA pan-cancer cohorts, SEC13 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated SEC13 data layer compared with 5 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher SEC13 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SEC13 expression acts as an unfavorable survival marker, although some lineages such as UCEC and READ show a favorable association.

MESO, UCEC, and KICH are the cancer types where SEC13 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.415	0.666	<.001	108	view →
UCEC	DFS	Median	III,IV	0.701	0.427	.001	88	view →
KICH	DFS	Median	II,III,IV	0.683	1.000	.001	88	view →
BRCA	OS	Median	All	0.894	0.949	<.001	77	view →
LIHC	OS	Median	All	0.704	0.837	<.001	69	view →
LUSC	OS	Median	II,III,IV	0.534	0.727	<.001	61	view →
ACC	DFS	Median	All	0.256	0.639	<.001	55	view →
SARC	DFS	Median	All	0.411	0.615	<.001	36	view →
READ	DFS	Quartile	All	0.917	0.737	.016	32	view →
LUAD	OS	Median	All	0.289	0.429	<.001	24	view →
DLBC	OS	Quartile	All	1.000	0.456	.010	17	view →
LGG	OS	Tertile	All	0.755	0.857	.007	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

SEC13–MESO (OS)

Open the MESO breakdown →